How the Brain Cleans Itself During Sleep: The Glymphatic System

Brain cross-section showing cerebrospinal fluid flow through glymphatic channels during deep sleep

The glymphatic system pumps cerebrospinal fluid through the brain during deep sleep, clearing amyloid beta and tau proteins linked to Alzheimer’s. One night of sleep deprivation raises amyloid by 5% on PET scan. Here is the full mechanism and what disrupts it.

Creatine for Brain Health: What the Research Actually Shows

Creatine molecule and brain neurons illustrating cognitive enhancement research

Creatine supplementation at doses of 10-20g daily improves memory, working memory, and cognitive resilience by replenishing ATP through the phosphocreatine system. A 2018 meta-analysis in the British Journal of Nutrition confirmed these effects across six randomized controlled trials.